Ponente
Descripción
Experimental evidence suggests that acute myeloid leukemia may originate from multiple clones of malignant cells; however it is unknown how the observed leukemic clones may differ with respect to cellular properties, such as proliferation and self-renewal. There is not much information about how the properties of cells change due to chemotherapy and relapse. Using mathematical models, the influence of cell properties on the multiclonal composition of acute myeloid leukemia is investigated. The results show that self-renewal is a key mechanism in the clonal selection process. Simulations suggest that high rates of cell proliferation and self-renewal dominate at primary diagnosis, whereas relapse after therapy-induced remission is triggered mainly by increased self-renewal, while proliferation rate is less representative. The high toxicity of many of the substances used in chemotherapy motivated us to explore in computer simulations the effects that they could cause during a period after the application of chemotherapy.
