II Simposio Internacional de Ciencia de los Materiales

Gadolinium(III) based contrast agents with potential applications in the early detection of Alzheimer's disease

No programado

20m

Centro Demostrativo de Energía Renovables (Quinta de los Molinos)

Poster Modificación de superficies y funcionalización de materiales Nanociencia y Ciencias de Materiales

Ponente

Gabriel Rafael Guerrero Porras (Laboratory of Bioinorganic, Faculty of Chemistry, University of Havana)

Descripción

Alzheimer's disease (AD) is characterized by an early aggregation of beta amyloid peptides (βA) in the brain. These structures could be visualized by Magnetic Resonance Imaging (MRI), for which it is necessary contrast agents (CAs) functionalized with compounds with high affinity to βA. Today, in the clinic, the implementation of metal (Fe, Mn or Gd) oxide nanoparticles and paramagnetic complexes as CAs are an interesting research field. In this sense, in CNEURO have been synthesized different monosubstituted naphthalene derivatives (Amylovis®), which are related to βA according to encouraging in silico, in vitro and in vivo evaluations carried out. Thus, the aim of this work is to conjugate one of the Amylovis® compounds to Gd2O3NPs and DOTA derivatives for the design of CAs that allow the early detection of βA by MRI. The obtained systems were characterized by FT-IR, NMR and MS spectroscopic techniques, as well as TEM, DLS, TGA and Potential ζ. The relaxivity values of the Gd2O3NPs, as well as in silico studies of the ligands allow to assure their potential use as ACs for the proposed purpose.