Ponente
Descripción
Thiourea derivatives are molecules that contain a simple functional nucleus composed of two nitrogen atoms and one sulfur atom that show great versatility for coordination with various metal centers. In addition to their potential antioxidant and anticancer properties, these molecules are of significant interest due to the high affinity of thiocarbonyl sulfur for transition metal surfaces such as gold. On the other hand, gold nanoparticles (AuNPs) can be synthesized with different sizes and shapes, and it is possible to modify their surface with various molecules that show biological activity. In this way, AuNPs functionalized with organosulfur molecules have shown potential applications in personalized medicine directed at therapeutic targets. This paper presents the results of the synthesis and characterization of AuNPs functionalized with the thiourea derivative 1-(2-furoyl)-3-phenylthiourea (AuNPs-T1). Both AuNPs and AuNPs-T1 were studied using Ultraviolet-Visible (UV-vis) and Infrared (FT-IR) spectroscopy, Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) and their Z potential. AuNPs were obtained by a variant of the Turkevich method, obtaining AuNPs with sizes between 20-25 nm. The efficiency of functionalization of the AuNPs was confirmed by UV-vis spectra, FTIR, and DLS data and Z potential. There was a shift of the T1 thioamide bands due to their association with the AuNPs surface.
Acknowledgments: We would like to thank the support of PREI-DGAPA for the invited professor to MPHS and project PN223LH010-011 of the National Program of the Basic and Naturals Science (PNCByN).
