Ponente
Descripción
Magnetic fluid hyperthermia is a therapeutic medical approach that uses the inductive heating of superparamagnetic iron oxide nanoparticles (SPION) under an external alternating magnetic field. Raising the temperature in tumor cells above the physiological values, between 40°C and 45°C, is cytotoxic, inhibits tumor growth and sensitizes it to primary treatment. Iron oxides, especially magnetite, have properties that turn them into ideal particles for magnetic hyperthermia. High saturation magnetization values, lack of toxicity and the possibility of controlling the size of SPION are parameters that strongly influence the specific absorption rate (SAR) of heat. In this study, iron oxide nanoparticles anchored with oleic acid were synthesized by the co-precipitation method, and then, with a ligand exchange procedure with dimercaptosuccinic acid, the dispersion of particles in water was achieved. The nanoparticles obtained were encapsulated with chitosan using ultrasound-assisted manufacturing systems. The morphology, size distribution and composition of the nanocomposite particles were determined by several techniques, such as atomic force microscopy, laser diffraction, Fourier transform infrared spectroscopy and X-ray diffraction, respectively. The hyperthermic properties were determined using the initial slope, corrected slope and Box-Lucas methods for SAR calculations. The study was carried out varying frequency and power of the applied magnetic field and high values of saturation temperature (ΔT) up to 31°C were measured.
