Ponente
Descripción
Clays are highly effective in cosmetology and dermatology. Bentonite (Bent) laminar clay, in particular, is widely used for their adsorbent properties, effectively reducing and controlling oil on the skin and scalp. They also offer protection against ultraviolet radiation. The development of hybrid materials based on a natural Cuban Bent, along with drugs as the L-ascorbic acid (LAA) and metformin hydrochloride (MET), offers a promising approach for creating new active ingredients in skin care formulations. Bent/LAA and Bent/MET hybrids obtained were characterized using X-ray diffraction (XRD), infrared (IR) spectroscopy, thermogravimetric analysis (TG) and zeta potential measurements The presence of both drugs (LAA and MET) in the clay was confirmed, along with the photoprotective effect of Bent on the LAA molecule. Structural characterization suggests that MET may be adsorbed on the Bent surface and/or intercalated into the interlayer space, oriented according to its thickness. Hydrogen bonds and van der Waals forces are likely the primary drivers of clay/MET interactions. On the other hand, LAA incorporation primarily occurs within the interlayer space via electrostatic interactions. Moreover, the antioxidant capacity of the drug was preserve in the Bent/LAA nanohybrid material.
Palabras claves: Clay, Bentonite, L-ascorbic acid, Metformin and Hybrid materials
