Ponente
Descripción
Antecedents: The sea represents a promising source for bioactive compounds. Marine organisms living in unique ecological conditions and great taxonomic diversity can synthesize molecules without equivalence to those found in terrestrial organisms. They offer the possibility of deriving in novel chemical structures with sui generis pharmacological effects. In particular, the search for anticancer agents from marine resources has gained attention in recent decades. Thalassia testudinum seagrass derivatives have been extensively evaluated due to its potential antitumor and antimetastatic effects. One extract from the leaves of the plant containing polyphenols, flavonoids, proanthocyanidins, among other structures up to 1000 µg/mL is not toxic to normal cells, meanwhile, it induces loss viability on different tumor cells. Objetives: Here we provide evidence of antitumor activity of testudinum metabolites. Results: In vitro (100-200 µg/mL) and in vivo (100 mg/kg) studies showed that antitumor activity of T. testudinum metabolites is associated, at least in part, with reactive oxygen species overproduction, immunogenic cell death and pro-apoptotic mechanisms in the tumor cells. T. testudinum extract treatment triggers ATF4-P53-NFκB specific gene expression and autophagy stress pathways. Data show suppression of cancer cell growth, cell motility and angiogenesis pathways in vitro and promotes antitumor immunogenic cell death in vivo. Conclusions: Altogether, these evidences suggest promising antitumor properties of the marine plant T. testudinum.
Keywords: Thalassia testudinum, marine biodiversity, antitumor properties.
Bibliography.
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